In testing the new wysiwyg interface on my first WordPress 2.0 blog, I experienced problems with inserting hyperlinks when using FireFox 1.5 as my browser (these problems disappeared when I switched to Internet Explorer).
Specifically, the dialog box that pops up when you click on the insert hyperlink button is truncated such that approximately the last 25% of the content that displays in that window is cut off. Furthermore, the window is not resizeable, nor does it have scrollbars. As a result, the user is unable to see the full URL that they are entering for the hyperlink (and can reach a point where they are essentially typing blindly because once your text enters the truncated portion, you can't see anything that you're typing). This same problem is encountered when one tries to enter a title for the hyperlink.
Given that hyperlinking is a significant component of blogging, and that a percentage of the WP community uses Firefox as their browser of choice, being forced to use IE in order to have full functionality of WP 2.0 admin interface is dismaying.