Using the new 'xmlrpc_methods' plugin hook, I tried to create a new XML-RPC method via a plugin. My plugin code is contained in a class to avoid namespace issues (See: http://codex.wordpress.org/Plugin_API#Avoiding_Function_Name_Collisions ).
I added the method to the method list using the class object array method ( $callback=array(&$myobject, 'methodname') ), but IXR_Server cannot execute methods declared in this manner. As a result, the only way to implement XML-RPC server methods inside a class is to extend the IXR_Server class, which can't be done from the xmlrpc_methods hook in WordPress.